This series is the last of the year between the two, and San Diego won two of three at home in their first series in May. The Cincinnati Reds (43-38), who have won 14 of their last 17 games, will host the San Diego Padres (37-44), who have lost five straight and are 2-8 over their last 10 games. Two teams going in opposite directions will begin the first game of a three-game set on Friday afternoon.